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1. www.sps.tsinghua.edu.cn › info › 1011储凌, PhD-清华大学药学院 - Tsinghua University簡

   www.sps.tsinghua.edu.cn › info › 1011

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   基于新型生物正交反应的beyond-Rule-of-5 (bRo5) 小分子细胞内合成、筛选与递送 人类基因组中含有约3000个与疾病相关的基因，但能被传统的符合“类药五原则”小分子靶向的蛋白只有600-1500个。

2. pubmed.ncbi.nlm.nih.gov › 31483909Drug Syntheses Beyond the Rule of 5 - PubMed

   pubmed.ncbi.nlm.nih.gov › 31483909

   2020年1月2日 · Drugs in the chemical space beyond the rule of 5 (bRo5) can modulate targets with difficult binding sites while retaining cell permeability and oral absorption. Reviewing the syntheses of bRo5 drugs approved since 1990 highlights synthetic chemistry's

   • 作者: Mohit Tyagi, Fabio Begnini, Vasanthanathan Poongavanam, Bradley C. Doak, Jan Kihlberg

   • Publish Year: 2020

3. 其他人也問了

   What is bro5 chemistry?

   • Drugs in the chemical space beyond the rule of 5 (bRo5) can modulate targets with difficult binding sites while retaining cell permeability and oral absorption. Reviewing the syntheses of bRo5 drugs approved since 1990 highlights synthetic chemistry's contribution to drug discovery in this space. In …

   Drug Syntheses Beyond the Rule of 5 - PubMed

   pubmed.ncbi.nlm.nih.gov/31483909/

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   What is bro5 pharmacology?

   • 2 Department of Medicinal Chemistry, MIPS, Monash University, 381 Royal Parade, Parkville, Victoria, 3052, Australia. Drugs in the chemical space beyond the rule of 5 (bRo5) can modulate targets with difficult binding sites while retaining cell permeability and oral absorption.

   Drug Syntheses Beyond the Rule of 5 - PubMed

   pubmed.ncbi.nlm.nih.gov/31483909/

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   What can we learn from discovery of bro5 compounds?

   • We present here highlights and case studies of lessons learned from discovery of bRo5 compounds. A simple multiparametric scoring function (AB-MPS) was devised that correlated preclinical PK results with cLogD, number of rotatable bonds, and number of aromatic rings. To access this article, please review the available access options below.

   Beyond the Rule of 5: Lessons Learned from AbbVie’s Drugs and Comp…

   pubs.acs.org/doi/10.1021/acs.jmedchem.7b00717

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   Does synthetic chemistry contribute to bro5 drug discovery?

   • Reviewing the syntheses of bRo5 drugs approved since 1990 highlights synthetic chemistry's contribution to drug discovery in this space. Initially, bRo5 drugs were mainly natural products and semi-synthetic derivatives.

   Drug Syntheses Beyond the Rule of 5 - PubMed

   pubmed.ncbi.nlm.nih.gov/31483909/

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4. www.sohu.com › a › 407006040_120335697JMC | GSK重新评估类药五规则在药物发现中的意义_clogP - 搜狐簡

   www.sohu.com › a › 407006040_120335697

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   2020年7月11日 · 辉瑞公司资深药物化学家Lipinski在2001年提出的筛选类药分子的五条基本法则，简称，Rule of 5 (Ro5),其内容是：分子量小于500，氢键供体的数量不超过5个，氢键受体的数量不超过10个，化合物的油水分配系数的对数值 (clogP) 不超过5。 在USAN药物中，惊讶地发现高MW和高logP的组合仅占1%。 在口服活性药物数据集中，少有批准的口服药物违反两个或更多的参数。 作者考虑数据的其他注释，在以下各节中讨论五规则背后的行为模式、改进及含义，借此来为药物发现提供新见解并建立原则。 亲脂性. 化合物在正辛醇和水中的分配系数比值的对数值已成为评估亲脂性的既定方法，这对脂蛋白而言是一个很好的折中方案。 亲脂性估计是一种非常有用的模型，在药物发现中具有一定的影响和实用性。

5. pubs.acs.org › doi › 10Beyond the Rule of 5: Lessons Learned from AbbVie’s ...

   pubs.acs.org › doi › 10

   2017年9月19日 · We present here highlights and case studies of lessons learned from discovery of bRo5 compounds. A simple multiparametric scoring function (AB-MPS) was devised that correlated preclinical PK results with cLogD, number of rotatable bonds, and number of aromatic rings.

   • 作者: David A. DeGoey, Hui-Ju Chen, Philip B. Cox, Michael D. Wendt

   • Publish Year: 2018

6. www.youtube.com › watchBro5 - 瘋悲催 @ 第四屆舞動馬拉松 - YouTube

   www.youtube.com › watch

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   2013年4月23日 · 第四屆舞動馬拉松表演嘉賓：Bro5如要轉載請註明 轉自：何浩文香港官方影迷會

   • 影片時長: 5 分鐘
   • 觀看人次: 67

   • 作者: DominicOHKFC

7. www.drugdiscoverychemistry.com › 23 › bro5bRo5 Macrocyclics, Degraders and More 2023 Archive

   www.drugdiscoverychemistry.com › 23 › bro5

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   At Cambridge Healthtech Institute’s 2nd Annual bRo5 conference, join fellow medicinal, computational, and synthetic chemists to discuss success stories and survey the field to discuss strategies for addressing these newer ‘large small molecule’ drug modalities.

8. baike.baidu.hk › item › Bro5Bro5_百度百科

   baike.baidu.hk › item › Bro5

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   BRO5的第一首主打歌名為《七日之癢》，由阮民安Tommy及成員LaYing作曲，張繼聰及LaYing作詞，是一首慢版R&B風格的情歌，配合他們自創編排的舞蹈，必能帶給觀眾耳目一新的感覺。