搜尋結果
Type XVIII collagen functions to provide strength, structural integrity, and cohesiveness to the basement membrane region in endothelial and epithelial cells of many different types of tissues. When type XVIII collagen is mutated at the COL18A1 gene, exon 2 in the sequence is skipped, which results in production of an early termination codon in exon 4 of this gene's transcript.
Genomics. 11 (1): 145–53. doi: 10.1016/0888-7543 (91)90111-Q. PMID 1765372. Chu ML, Pan TC, Conway D, et al. (1989). "Sequence analysis of alpha 1 (VI) and alpha 2 (VI) chains of human type VI collagen reveals internal triplication of globular domains similar to the A domains of von Willebrand factor and two alpha 2 (VI) chain variants that ...
Collagen alpha-1 (VII) chain is a protein that in humans is encoded by the COL7A1 gene. [5] It is composed of a triple helical, collagenous domain flanked by two non-collagenous domains, and functions as an anchoring fibril between the dermal-epidermal junction in the basement membrane. [6] Mutations in COL7A1 cause all types of dystrophic ...
A tendon or sinew is a tough band of dense fibrous connective tissue that connects muscle to bone. It sends the mechanical forces of muscle contraction to the skeletal system, while withstanding tension . Tendons, like ligaments, are made of collagen. The difference is that ligaments connect bone to bone, while tendons connect muscle to bone.
The word collagen itself derives from Greek κόλλα (kolla), meaning 'glue'. These proteins form a molecular bond with the glued object. [ citation needed ] Conventionally, keratin glues , while made from animal parts like horns and hooves, are not considered animal glues as they are not collagen glues.
Collagen alpha-5 (IV) chain is a protein that in humans is encoded by the COL4A5 gene . This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. Mutations in this gene are associated with X-linked Alport syndrome, also known as hereditary nephritis. Like the other members of the type ...
View/Edit Mouse. Collagen alpha-1 (VIII) chain is a protein that in humans is encoded by the COL8A1 gene. [5] [6] This gene encodes one of the two alpha chains of type VIII collagen. The gene product is a short chain collagen and a major component of the basement membrane of the corneal endothelium. The type VIII collagen fibril can be either a ...
