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  1. 5 天前 · Pancreatic cancer does not usually cause any symptoms until its later stages, when it has spread to other parts of the body. As the cancer progresses, people may develop jaundice, weight loss ...

  2. 2 天前 · Pancreatic cancer is a rare disease, accounting for about 3% of all cancers in the United States. It is the deadliest of all solid malignancies, accounting for about 7% of all cancer deaths each year, and carries a 5-year survival rate of just 11.5%.

  3. 4 天前 · Pancreatic ductal adenocarcinoma, frequently referred to as pancreatic cancer, makes up the vast majority (~90%) of all pancreatic neoplasms and remains a disease with a very poor prognosis and high morbidity. Epidemiology. Pancreatic cancer accounts for 22% of all deaths due to gastrointestinal malignancy, and 5% of all cancer deaths 1.

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  5. 3 天前 · PURPOSE CT041 is a chimeric antigen receptor (CAR)–modified T-cell therapy that specifically targets claudin18.2 in solid tumors. Here, we report the pooled analysis results of two exploratory clinical trials to evaluate CT041 in patients with previously treated pancreatic cancer (PC). PATIENTS AND METHODS These two multicenter, open-label phase I/Ib trials (CT041-CG4006, CT041-ST-01) have a ...

  6. 4 天前 · Pancreatic adenocarcinoma is the seventh leading cause of cancer deaths worldwide, with 496,000 new cases and 466,000 deaths in 2020 [ 1 ]. Patients are typically diagnosed at an advanced stage...

  7. 5 天前 · Abstract. Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of cancer-related death worldwide, primarily due to its rapid progression. The current treatment options for PDAC are limited, and a better understanding of the underlying mechanisms responsible for PDAC progression is required to identify improved therapeutic strategies. Here, we identified FBXO32 as an oncogenic ...

  8. 5 天前 · Pancreatic cancer is a highly fatal disease, and existing treatment methods are ineffective, so it is urgent to develop new effective treatment strategies. The high dependence of pancreatic cancer cells on glucose and glutamine suggests that disrupting this

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