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Indications and Dosage. Oral. Hereditary transthyretin-mediated amyloidosis cardiomyopathy, Wild-type transthyretin-mediated amyloidosis cardiomyopathy. Adult: To decrease CV-related hospitalisation and mortality: As tafamidis 61 mg cap (equivalent to tafamidis meglumine 80 mg): 1 cap once daily. As tafamidis meglumine 20 mg cap: 4 caps once daily.
Primary hypercholesterolaemia (heterozygous familial or nonfamilial) & mixed dyslipidaemia Adult Initial dose: 10 or 20 mg once daily; 40 mg daily in patients requiring >45% reductions in LDL-cholesterol. Maintenance dose: 10-80 mg once daily. Heterozygous familial hypercholesterolaemia Childn ≥10 yr 10 mg once daily.
Adult: As adjunctive therapy for respiratory tract disorders associated with excessive, viscous mucus: As 10% solution: 6-10 mL 3-4 times daily; if necessary, may give 2-20 mL 2-6 hourly. As 20% solution: 3-5 mL 3-4 times daily; if necessary, may give 1-10 mL 2-6 hourly. In preparation for diagnostic bronchial studies (bronchograms ...
Hypertensive crisis. Adult: 150-300 mcg given via slow inj over 10-15 minutes, dose may be repeated up to Max 750 mg over 24 hours. Oral. Attention deficit hyperactivity disorder. Child: 6-17 years As monotherapy or as adjunctive therapy to psychostimulant: As extended-release tab: Initially, 100 mcg at bedtime, increase by 100 mcg/day in ...
Indications and Dosage. Intravenous. Locally advanced urothelial carcinoma, Metastatic urothelial carcinoma. Adult: 1.2 g once every 3 weeks via infusion over 60 minutes, until disease progression or unacceptable toxicity. Dose modification, interruption, or discontinuation (based on severity) may be required if immune- or infusion-related ...
Indications and Dosage. Adult: For patients unresponsive to conventional standard therapy or with low cardiac output post-cardiac surgery: Initially, a loading dose of 50 mcg/kg by slow inj over 10 minutes followed by continuous maintenance infusion of 0.375-0.75 mcg/kg/min. Adjust according to haemodynamics and clinical response.
