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  1. Split dose regimen (bd): Initially 60 mg/day as 45 mg + 15 mg (45 mg taken upon waking & prior the morning meal & 15 mg taken 8 hr later). Titrate upward to 90 mg/day (60 mg + 30 mg), then to a target dose of 120 mg/day (90 mg + 30 mg), if tolerated, w/ at least wkly intervals between titrations. Click to view Jinarc detailed prescribing ...

  2. Search drug information, interaction, images & medical diagnosis. The most comprehensive database of medicines available in China, Hong Kong, Taiwan, Malaysia, Singapore, Philippines, Vietnam, Thailand, Indonesia and India Register for a MIMS account and ...

  3. Reduce sildenafil clearance w/ CYP450 isoforms 3A4 & 2C9 inhibitors. Reduces sildenafil clearance w/ CYP3A4 inhibitors (eg, ketoconazole, erythromycin, cimetidine). Potential serious interaction w/ nicorandil. Potentiate the hypotensive effects w/ nitrates.

  4. Search drug information, interaction, images & medical diagnosis. The most comprehensive database of medicines available in China, Hong Kong, Taiwan, Malaysia, Singapore, Philippines, Vietnam, Thailand, Indonesia and India Register for a MIMS account and ...

  5. special reports. In an interview with MIMS Doctor, Dr Ka-Yuen Lock, Specialist in Endocrinology, Diabetes and Metabolism in Hong Kong, discussed management of diabetes mellitus (DM), including use of ultra-long-acting insulin, in optimizing glycaemic control. She also shared a case study illustrating improvements in glucose variability and ...

  6. Childn 2-11 yr Dose up to 35 mL/kg/day should be regularly adjusted to the requirements of the paed patient that varies more than in adult patients. SmofKabiven Peripheral Adult & adolescents (12-16/18 yr) 20-40 mL/kg/day. Max: 40 mL/kg/day. Childn 2-11 yr Dose up to 40 mL/kg/day should be regularly adjusted to the requirements of the paed ...

  7. Adult: 420 mg once daily, continue until disease progression or unacceptable toxicity. If toxicity occurs, withhold doses until recovery to baseline or grade 1. Restart treatment at the starting dose for the 1st occurrence, then reduce by 140 mg after the 2nd occurrence, another reduction of 140 mg may be considered if needed.

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