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新型 WEE1i APR-1051 是治療細胞週期蛋白 E 過度表達癌症的一種潛在耐受性良好且有效的治療方法. 這張海報總結了 APR-1051 的臨床前數據. APR-1051 在體外表現出高的 WEE1 抑制效力. 選擇性是成功的關鍵。 APR-1051 顯示出 PLK 激酶家族的低脫靶抑制作用。 爲了測量 PLK 家族酶抑制脫靶的可能性，進行了體外實驗，以確定 APR-1051 與 Zn-C3 的 IC50（Zentalis Pharmaceuticals） 結果顯示，與鋅C3相比，APR-1051 的IC50值更高，PLK1、PLK2和PLK3的偏離靶嚮明顯降低。 APR-1051 的 IC50 優於 Zn-C3 的 IC50. • PLK1：> 150 倍.
2024年4月14日 · While attending the 4th China International Consumer Goods Fair, Porsche China President and CEO Michael Kirsch (Michael Kirsch) responded to the new Xiaomi SU7 product dubbed “Michele” by netizens. “As for the similarities between the Xiaomi SU7 and ...
2024年4月13日 · Breakings · Apr 13 06:01. On the one hand, there is pressure on interest spreads from bank operations, and on the other, fiercely competitive savings collection pressure. Many grass-roots bank branches have created high-interest savings collection chaos such as “manual interest payments.” The hidden risks behind this cannot be ignored.
Dada Group has both offense and defense. On the one hand, it can withstand the impact of platforms such as Meituan Flash Shopping and maintain its “fast” advantage, and at the same time expand a new growth curve. Incremental attack: Sinking is not good for falling in love with war; improving quality and service is the long-term path.
At the beginning of 2021, John Lam, an analyst in charge of real estate research at UBS Greater China, gave a rare sales rating to China's Evergrande Group, which shocked the market at one point. A few months later, Evergrande officially stormed, proving John Lam's foresight.
2023年6月5日 · Modulation of Wnt signaling pathways has potential for treatment of degenerative diseases and tissue injuries. Surrozen's platform and proprietary technologies have the potential to overcome the limitations in pursuing the Wnt pathway as a therapeutic strategy.
2022年7月26日 · A subsidiary of the company) filed a winding-up petition for winding up Hop Fung Lung case No. HCCW255/2022 to the High Court of the Hong Kong Special Administrative region. The petition will be heard in court at 10:00 on September 28th, 2022. The main reason for filing the petition against Hop Fung Lung is that Hop Fung Lung failed to pay HK ...
