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  1. Adult: To reduce the risk of invasive breast cancer in postmenopausal women with osteoporosis and postmenopausal women with high risk of invasive breast cancer: 60 mg once daily for 5 years. Recommended therapeutic indications may vary between countries (refer to specific product guidelines).

  2. Metabolism: Extensively metabolised in the liver by CYP enzymes, including CYP2D6 to active and inactive metabolites, including desmethyl- and didesmethylchlorphenamine; undergoes extensive first-pass metabolism. Excretion: Mainly via urine (approx 22%

  3. Metered-dose inhaler releasing fluticasone 250 mcg and formoterol 10 mcg per actuation. Initially, 2 puffs bid, titrated to the lowest effective dose and may be increased by switching to next highest strength combination, depending on patient’s response. Child: Available preparations:

  4. Adult: For short-term symptomatic treatment of acute moderate pain, when administration by IV route is clinically justified or when other routes of administration are not possible: 400-800 mg 6 hourly as necessary via IV infusion over 30 minutes. Max: 3,200 mg daily.

  5. Undergoes extensive first-pass metabolism in the gastrointestinal mucosa and liver. Excretion: Mainly via the bile; urine (<2% as unchanged drug). Elimination half-life: Approx 14 hours (atorvastatin); approx 20-30 hours (equipotent metabolites).

  6. Metabolism: Undergoes first-pass metabolism in the gut wall or liver. Metabolised by CYP2D6 to dihydromorphine and by CYP3A4 to nordihydrocodeine. Excretion: Via urine as unchanged drug and metabolites including glucuronide conjugates. Elimination half

  7. Dapsone. This information is not country-specific. Please refer to the Hong Kong prescribing information. Generic Medicine Info. Indications and Dosage. Oral. Prophylaxis of malaria. Adult: In combination with pyrimethamine: 100 mg weekly. Oral. Paucibacillary leprosy.

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