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1. www.ncbi.nlm.nih.gov › pmc › articlesVibrio vulnificus Hemolysin: Biological Activity, Regulation ...

   www.ncbi.nlm.nih.gov › pmc › articles

   2020年10月23日 · The Vibrio vulnificus (V. vulnificus) hemolysin (VVH) is a pore-forming cholesterol-dependent cytolysin (CDC). Although there has been some debate surrounding the in vivo virulence effects of the VVH, it is becoming increasingly clear that it drives different cellular outcomes and is involved in the pathogenesis of V. vulnificus.

   • 作者: Yuan Yuan, Zihan Feng, Jinglin Wang
   • DOI: 10.3389/fimmu.2020.599439

   • Publish Year: 2020
   • Publication: Front Immunol. 2020; 11: 599439.

2. www.cell.com › trends › microbiologyComplex regulatory networks of virulence factors in Vibrio ...

   www.cell.com › trends › microbiology

   2022年6月23日 · Cytolysin/hemolysin VvhA is a pore-forming toxin conferring powerful hemolytic activity to V. vulnificus [39,40]. VvhA triggers apoptosis, necrotic cell death, and autophagy by dysregulation of host cell signaling, leading to host tissue damage [41,42].

3. 其他人也問了

   What is hemolysin VvhA?

   • Cytolysin / hemolysin VvhA is a pore-forming toxin conferring powerful hemolytic activity to V. vulnificus [ 39, 40 ]. VvhA triggers apoptosis, necrotic cell death, and autophagy by dysregulation of host cell signaling, leading to host tissue damage [ 41, 42 ].

   Complex regulatory networks of virulence factors in Vibrio vulnificus

   www.sciencedirect.com/science/article/pii/S0966842X22001214

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   Does Vibrio vulnificus VvhA induce NF- B-dependent mitochondrial cell death?

   • Lee, SJ., Jung, Y., Oh, S. et al. Vibrio vulnificus VvhA induces NF- κ B-dependent mitochondrial cell death via lipid raft-mediated ROS production in intestinal epithelial cells.

   Vibrio vulnificus VvhA induces NF-κB-dependent mitochondrial ... - Nat…

   www.nature.com/articles/cddis201519

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   What is VvhA gene in Vibrio vulnificus?

   • The vvhA gene is found in most V. vulnificus isolates, which was often used as a detecting marker for V. vulnificus (17, 18). However, unlike other Vibrio spp. such as V. cholerae and V. parahaemolyticus, where distinct molecular attributes, such as toxin genes, are normally associated with clinical strains (19, 20).

   Vibrio vulnificus Hemolysin: Biological Activity, Regulation of vvhA

   www.ncbi.nlm.nih.gov/pmc/articles/PMC7644469/

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   What role does VvhA play in the pathogenesis of V vulnificus?

   • However, other studies have confirmed that vvhA gene is substantially regulated and expressed in vivo and is likely to play important roles in the pathogenesis of V. vulnificus (10, 11). For example, V. vulnificus is known for a siderophilic bacterium and iron as one of the factors that regulate vvhA expression (12 – 14).

   Vibrio vulnificus Hemolysin: Biological Activity, Regulation of vvhA

   www.ncbi.nlm.nih.gov/pmc/articles/PMC7644469/

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4. www.nature.com › articles › cddis201519Vibrio vulnificus VvhA induces NF-κB-dependent ...

   www.nature.com › articles › cddis201519

   2015年2月19日 · The Gram-negative bacterium Vibrio vulnificus produces hemolysin (VvhA), which induces cytotoxicity in mammalian cells. However, our understanding of the cytotoxic mechanism and the modes of ...

   • 作者: Lee Sj, Jung Yh, Oh Sy, Song Ej, Choi Sh, Han Hj

   • Publish Year: 2015

5. www.nature.com › articles › srep27080Vibrio vulnificus VvhA induces autophagy-related cell death ...

   www.nature.com › articles › srep27080

   2016年6月2日 · VvhA, a virulent factor of Vibrio (V.) vulnificus, induces acute cell death in a destructive manner. Autophagy plays an important role in cell death, but the functional role of VvhA in...

   • 作者: Eun Ju Song, Sei-Jung Lee, Hyeon Su Lim, Jun Sung Kim, Kyung Ku Jang, Sang Ho Choi, Ho Jae Han

   • Publish Year: 2016

6. www.sciencedirect.com › science › articleReview Complex regulatory networks of virulence factors in ...

   www.sciencedirect.com › science › article

   2022年12月1日 · A recent study further revealed that IscR directly activates the expression of vvhA under nitrosative stress and iron starvation [62]. VvhA induced by IscR would disrupt host macrophages, epithelial cells, and erythrocytes, which contributes to immune evasion and

7. pubmed.ncbi.nlm.nih.gov › 33789126Sensitively and quickly detecting Vibrio vulnificus by real ...

   pubmed.ncbi.nlm.nih.gov › 33789126

   Vibrio vulnificus (V. vulnificus) is a Gram-negative bacterium living in warm and salty water. This marine bacterium could produce hemolysin (VVH), which often causes serious gastroenteritis or septicemia when people contact to seawater or seafood containing V. vulnificus. Timely diagnosis is regard as essential to disease surveillance.

8. onlinelibrary.wiley.com › doi › 10Molecular Microbiology | Microbiology Journal | Wiley Online ...

   onlinelibrary.wiley.com › doi › 10

   2013年4月8日 · VvhA produced by Vibrio vulnificus exhibits cytolytic activity to human cells including erythrocytes. Since haemolysis by VvhA may provide iron for bacterial growth and pathogenicity, we investigated the expression of VvhA to elucidate the regulatory roles of Fur, a major transcription factor controlling iron-homeostasis.