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  1. pubchem.ncbi.nlm.nih.gov › compound › dexamethasoneDexamethasone | C22H29FO5 | CID 5743 - PubChem

    The high ratio of systemic glucocorticoid activity to local anti-inflammatory activity of inhaled dexamethasone may be due to its greater water solubility and longer metabolic hal life after absorption relative to the other inhaled corticosteroids.

  2. www.tandfonline.com › doi › fullSolubilisation of dexamethasone: experimental data, ...

    2020年10月28日 · Experimental solubility of dexamethasone was obtained in binary aqueous mixtures of ethanol, methanol and acetonitrile at 298.2 K. The effects of micellization and pH were also investigated on the solubility of the drug.

    • Arezu Maheri, Peyvand Ghanbarpour, Elaheh Rahimpour, William E. Acree, Abolghasem Jouyban, Abolghase...
    • 2021

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  4. pubs.rsc.org › en › contentPolymorphs and isostructural cocrystals of dexamethasone: ...

    2022年7月29日 · The improved solubility of the DEX–CAT cocrystal may offer more bioavailability of DEX. Dexamethasone (DEX) is a corticosteroid drug used to treat arthritis and asthma and considered a promising drug for the treatment of COVID-19. The major drawback of DEX is its poor aqueous solubility (89 mg L−1).

  5. pubs.acs.org › doi › 10Dexamethasone: Insights into Pharmacological Aspects, ...

    2022年4月19日 · However, DEX usage is often restricted in the clinic due to its poor water solubility. When administered through a systemic route, it can elicit severe side effects, such as hypertension, peptic ulcers, hyperglycemia, and hydro-electrolytic disorders.

  6. www.sciencedirect.com › science › articlePharmacokinetics, Pharmacodynamics, and Comparative ...

    2011年11月1日 · According to the Biopharmaceutical Classification System, dexamethasone is a class 1 drug (high permeability and high solubility). 24 However, the solubility of dexamethasone is comparatively low for a class 1 drug (q = 0.238), and dissolution was shown to be

    • Christian Queckenberg, Bertil Wachall, Valerie Erlinghagen, Paola Di Gion, Dorota Tomalik-Scharte, M...
    • 2011

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  8. www.ncbi.nlm.nih.gov › pmc › articlesPhysical and Chemical Stability of Dexamethasone Sodium ...

    2019年11月15日 · The pure drug substance of dexamethasone is a white crystalline powder that is practically insoluble in water (≤0.1 mg/mL). 1,12 Dexamethasone phosphate is a water-soluble phosphate ester of dexamethasone with 2 added acidic groups (pK a values of 1.89 13

  9. www.ncbi.nlm.nih.gov › pmc › articlesDexamethasone Conjugates: Synthetic Approaches and Medical ...

    2021年3月27日 · DEX is a lipophilic substance with a solubility in water of 100 μg/mL; accordingly, DEX is soluble in acetone, ethanol, and chloroform.