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2020年2月25日 · This opens a possibility that manipulating the cellular metabolism of T cells may provide a new, promising therapeutic intervention to modulate the balance between pathogenic Th17 and Treg cells in chronic autoimmune disorders. The research is published in the journal Cell Reports.
- Inhibiting The JAK/STAT Pathway
- JAK/STAT Pathway and Interferon Gamma
- Molecular Control of MS Susceptibility Genes
- Development and Activity of CD4+ T Cells
JAK/STAT is a critical communications route that translates signals from outside a cell into instructions to the cell nucleus, including instructions that increase or decrease immune system activity. Previous lab research has shown that drugs which inhibit the JAK/STAT pathway may be beneficial in reducing inflammation in the brain. They may offer ...
One chemical signal that interacts with the JAK/STAT pathway is the cytokine interferon gamma. Chander Raman, Ph.D., is testing the hypothesis that increased levels of interferon gamma, working through the JAK-STAT Pathway, contributes to the progression and severity of MS. In his lab, Raman is identifying the subpopulations of CD4+ and CD8+ T cell...
Interleukin-10 is an anti-inflammatory signaling molecule produced by CD4+ T regulatory cells to lower immune system activity. Increasing IL-10 signals in patients with MS could offer a new treatment avenue. In their labs, Casey Weaver, Ph.D., and Scott Barnum, Ph.D., are uncovering the molecular mechanisms of IL-10 production in MS. They are focus...
CD4+ T cells play a crucial role in fighting off infections. They are also at the heart of the damaging immune response in multiple sclerosis. UAB researchers studying the function of CD4+ T cells are finding new ways to disrupt or reverse the multiple sclerosis disease process. In their labs, they are focusing on several key signaling molecules th...
2018年8月14日 · Our results expand these previous findings to now include stem-like CD4 T cells and also demonstrate similarities between CD4 T cells during autoimmune chronic inflammation and CD8 T cells in chronic viral infection and cancer.
Lift cells by scraping in PBS. Pellet the suspension of cells by centrifugation at 2,500 × g for 5 minutes. Discard the supernatant. Add Urea stock solution containing HALT protease inhibitor mix to the cell pellet. Use at least 1 ml of either Reagent for cell pellet from a 100mm plate (~0.5 - 2 mg protein). Pipette the mixture up and down to ...
Janet M. Turan. PhD Professor Health Policy and Organization RPHB 517D jmturan@uab.edu (205) 934-6780 Scholars Profile. An accredited school of public health in Alabama, UAB SOPH seeks to improve public health, safety, and well-being through research, education, and service.
2024年4月9日 · Thus, for the current study, they hypothesized that Tiam1-mediated maladaptive plasticity also contributes to morphine tolerance and hyperalgesia. They first found that prolonged morphine treatment markedly increased the amount of activated Tiam1 in spinal dorsal horn neurons and that Tiam1 remained activated after the seven-day morphine ...
2022年1月20日 · CD47 acts to suppress the activation of phagocytic macrophages and the infiltration of T cells, two arms of the body’s white blood cell immune response. Although white blood cells function to protect against illness and disease, these cells also participate in injury of organ grafts.
